Endocrine Abstracts

Introduction Immune reconstitution therapies (IRT), which include antibody-based cell-depleting therapies targeting CD52+ (alemtuzumab) or CD20+ (rituximab, ocrelizumab) leukocytes, are approved for the treatment of multiple sclerosis. Thyroid autoimmunity is a common adverse effect of alemtuzumab treatment, Graves' disease being the most prevalent manifestation. To date, thyroid autoimmunity events have not been reported with CD20 targeting monoclonal a...

Background: Ectopic ACTH secretion from metastatic acinic cell carcinoma (ACC) of the parotid gland is extremely rare. ACC is an uncommon, typically indolent, salivary gland neoplasm. Herein, we report a case of a high-grade ACC later diagnosed with Cushing’s syndrome (CS).Case presentation: A 60-year-old man presented with a laterocervical mass. Computed tomography (CT) documented a 39×38 mm mass on the parotid gland and homolateral cervical l...

Background: Agranulocytosis is rare and may develop in 0.2–0.5% patients using antithyroid drug therapy (ATD). We report on a patient who developed febrile neutropenia two weeks after starting treatment with methimazole.Case Report: A 74-year-old female, with no relevant medical history, was diagnosed with Graves disease and treated with methimazole (30 mg/day). Three weeks after starting therapy she presented to the emergency department with compla...

Introduction: Fine needle aspiration cytology(FNAC) is the mainstay for evaluation of nodular thyroid disease. Internationally reported prevalence for Bethesda I(unsatisfactory sample) category is 5-60%. Several factors may determine this result, including patient and nodules’ features as well as both FNAC performer and pathologists’ skills. Few studies have evaluated pre-procedure factors associated with unsatisfactory cytology results. If present, recognizing these...

Introduction and objectives: Lenvatinib is the first line treatment for advanced radioiodine refractory (RAIR) differentiated thyroid carcinoma (DTC). Poorly differentiated thyroid carcinoma (PDTC) outcomes with Lenvatinib have only been subjected to sub analysis in one PHASE III study (SELECT), which might limit its real-world use in PDTC. We intend to compare the effectiveness of Lenvatinib in metastatic RAIR DTC and PDTC patients.Methods: Retrospectiv...

Journal of Endocrinology, 2022, 252(1), 59-70 (DOI: https://doi.org/10.1530/JOE-21-0298): ...

Background: ROHHAD (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dys-regulation) syndrome is an uncommon disease with fatal outcome. Rapidly progressive obesity in early childhood along with altered hypothalamic and autonomic function and hypoventilation are characteristic features. Neuroendocrine tumors complicate approximately 40% of the ROHHAD cases (ROHHAD-NET). Early diagnosis of this extreme rare disease is hampered by the absence of...

Context: Pheochromocytomas and paragangliomas (PPGLs) are rare tumours with potentially harmful cardiovascular complications. Traditionally, they were detected in patients with symptoms and signs of catecholamine excess or during genetic surveillance. However, according to recent reports, PPGLs are increasingly being diagnosed in the setting of incidentally discovered adrenal masses.Aim: To assess the initial clinical presentation of our PPGL patients wi...

Introduction: Vitamin B1 (VB1) deficiency can occur in patients with obesity and after bariatric surgery (BS). Nevertheless, pre-operative measurements of VB1 are still controversial. The relationship between serum VB1 and weight loss after BS has not been reported previously.Objectives: To study the association between pre-operative VB1 levels and weight loss after BS.Methods: Retrospective study of patients submitted to bariatric...

Non-alcoholic fatty liver disease (NAFLD) is characterized by the pathological increase of lipid droplets, altered fat metabolism in hepatocytes and increased inflammation. Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF-α release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of pharmacological PDE4 inhi...